The CPBio at CIB-CSIC integrates 12 groups with expertise in structural, chemical and computational biology. Research at CPBio aims to understand the molecular basis of fundamental cell processes, in an effort to develop new substances with pharmacological interest.
In order to meet these challenges, the CPBio gathers a powerful combination of experimental and theoretical strengths in structural biology, biological and medicinal chemistry, mechanistic biochemistry, and molecular biophysics. Our research targets include carbohydrate recognition, pathogenic microorganisms, microtubules, transcription, DNA repair and immune response, with additional emphasis on cancer and neurological diseases. The resulting knowledge is expected to provide insight into essential biological functions, eventually leading to drug design and other biomedical applications.
Two major scientific areas are defined within the department.
|Structure of macromolecular complexes||_______Structure of macromolecular complexes|
|Fernández-Tornero Lab||Structure of macromolecular assemblies|
|Llorca Lab||Electron microscopy of macromolecules|
|Romero Lab||Structural biology of proteins|
|Vega Lab||Structure of host-pathogen interactions|
|Chemical biology and drug design||_____Chemical biology and drug design|
|Andreu Lab||Tubulins and FtsZ protein assemblies|
|Cañada Lab||NMR and molecular recognition|
|Díaz Lab||Microtubule stabilizing agents|
|Martín-Santamaría Lab||Computational chemical biology|
|Martínez Lab||Medicinal and biological chemistry|
|Pérez-Sala Lab||Posttranslational modification of proteins|
|Rivas Lab||Chemotherapeutic membrane-active peptides|
The CPBio was created within the CIB-CSIC at the end of last century, to meet the challenges of modern molecular biology. Originally named Protein Structure and Function, it pioneered the characterization of proteins using state-of-the-art technologies, including automated N-terminal sequencing and analytical ultracentrifugation. At the dawn of the new century, it was the first Spanish department to incorporate the three high-resolution structural biology techniques X-ray crystallography, nuclear magnetic resonance and electron microscopy in combination with complementary biophysical methods. Today, the CPBio has incorporated medicinal and biological chemistry groups, thus increasing the potential to translate our research to society.