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Chemical Physical Biology About


The Chemical and Physical Biology CPBio department is one of the five divisions within the Centre for Biological Research (CIB) of the Spanish National Research Council (CSIC).

The CPBio at CIB-CSIC integrates 12 groups with expertise in structural, chemical and computational biology. Research at CPBio aims to understand the molecular basis of fundamental cell processes, in an effort to develop new substances with pharmacological interest.

In order to meet these challenges, the CPBio gathers a powerful combination of experimental and theoretical strengths in structural biology, biological and medicinal chemistry, mechanistic biochemistry, and molecular biophysics. Our research targets include carbohydrate recognition, pathogenic microorganisms, microtubules, transcription, DNA repair and immune response, with additional emphasis on cancer and neurological diseases. The resulting knowledge is expected to provide insight into essential biological functions, eventually leading to drug design and other biomedical applications.

Two major scientific areas are defined within the department.

Structure of macromolecular complexes _______Structure of macromolecular complexes
Fernández-Tornero Lab Structure of macromolecular assemblies
Llorca Lab Electron microscopy of macromolecules
Romero Lab Structural biology of proteins
Vega Lab Structure of host-pathogen interactions
Chemical biology and drug design _____Chemical biology and drug design
Andreu Lab Tubulins and FtsZ protein assemblies
Cañada Lab NMR and molecular recognition
Díaz Lab Microtubule stabilizing agents
Martín-Santamaría Lab Computational chemical biology
Martínez Lab Medicinal and biological chemistry
Pérez-Sala Lab Posttranslational modification of proteins
Rivas Lab Chemotherapeutic membrane-active peptides

The CPBio was created within the CIB-CSIC at the end of last century, to meet the challenges of modern molecular biology. Originally named Protein Structure and Function, it pioneered the characterization of proteins using state-of-the-art technologies, including automated N-terminal sequencing and analytical ultracentrifugation. At the dawn of the new century, it was the first Spanish department to incorporate the three high-resolution structural biology techniques X-ray crystallography, nuclear magnetic resonance and electron microscopy in combination with complementary biophysical methods. Today, the CPBio has incorporated medicinal and biological chemistry groups, thus increasing the potential to translate our research to society.