Llorca Blanco, Oscar Antonio
91 837 3112 Extension: 4446/4436
Our group is interested in the study of the molecular mechanisms and the structural bases that regulate cellular processes controlled by large macromolecular complexes. Our major focus is on complexes with relevance in human health. We use 3D-Electron Microscopy to visualize these large complexes, providing structural information that we combine with biochemical and functional experiments to increase our mechanistic understanding of these processes.
Figure 1. Structure of the RuvBL1-RuvBL2
Our research is internationally recognized and our main impact has been made in the applicability of single-particle 3D-electron microscopy to “challenging” complexes. Many macromolecular complexes of interest are difficult to purify and analyse by X-ray crystallography alone, but they are also tricky targets for EM studies. We have devoted a significant part of our efforts to set up efficient methodological approaches to obtain reliable structural information by EM of these complexes.
Figure 2. Idealized model on the structure and function of properdin
Figure 3. Structural model for UPF1 activation.
We had a major impact in the study of transient and short-lived macromolecular interactions and flexible conformations with a functional relevance using three-dimensional electron microscopy. Llorca has published over 85 articles in top peer-reviewed journals, including Nature, Nature Structural and Molecular Biology, Molecular Cell, Genes and Development, EMBO Journal, Cell reports, Current Opinion in Structural Biology, PNAS USA, Journal of Clinical Investigation and Nucleic Acids Research, among others.