Our current scientific interest focuses in two major areas:
Macromolecular machines in DNA and RNA transactions (DNA repair, DNA replication and RNA degradation).
Macromolecular machines in DNA and RNA transactions (DNA repair, DNA replication and RNA degradation), supported by projects of the Spanish Ministry of Science (SAF2002, SAF2005, SAF2008, SAF2011). The study of these dynamic processes is at the frontier of structural biology and they are related to cancer and several genetic syndromes.
Our recent efforts are concentrating in the study of nonsense-mediated mRNA decay (NMD), a eukaryotic surveillance pathway that degrades aberrant mRNAs, the study of the eukaryotic pol-prim complex that initiates DNA replication and the role of the RuvBL1-RuvBL2 ATPases in these events.
Defining the molecular and structural mechanisms that regulate the complement system and their role in disease.
Defining the molecular and structural mechanisms that regulate the complement system and their role in disease. Complement is part of the innate immunity and a first responder for pathogens. Mutations and polymorphisms in complement genes associate with several human genetic diseases. As part of a project funded by the Autonomous Government of Madrid, in collaboration with Santiago Rodriguez de Córdoba (CIB), we characterize the structure of complexes regulating complement. These studies are providing a better understanding of the molecular basis of human diseases linked to complement, and contributing to design novel potentially useful reagents that target complement.