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The Translational medicinal and biological chemistry group is focused on the design, synthesis, biological evaluation, study and optimization of pharmacokinetic properties of structurally diverse chemical entities for drug discovery. The efforts of our group are focused on the discovery of innovative drugs with novel mechanisms of action as disease-modifying agents for unmet severe pathologies such as neurodegenerative and neglected diseases. Our group applies medicinal chemistry programs combining classical and computational medicinal chemistry.
For the design of our drugs (mainly small heterocyclic molecules with MW<500), different strategies are being used. These include computer-aided drug design, development of multifunctional compounds that bear different pharmacophore moieties in the same molecule to interact with different targets, and ADME properties improvement of selected candidates, among others. The group has developed an in-house chemical library (called MBC library) containing over 1200 compounds with privileged scaffolds which is continuously growing and extensively used in our directed biological and computational screening programs.
Our research entails a high content of translational research. The group’s research programs are designed from the early stages of drug discovery to proof of efficacy in representative animal models. Scientific collaborations and technology transfer to companies in the pharmaceutical sector are key tasks in achieving our goals.