Main Research Lines
Infectious diseases are the leading cause of death worldwide and are a major challenge for public health. Despite recent advances in biochemical and structural studies of a series of pathogenic factors, a better understanding of targets involved in antibiotic resistance and microbial pathogenesis and how they are transferred is important to combat infectious diseases. Approaches to combat bacterial infection rely on, 1) the disruption of the bacteria growth cycle by preventing the synthesis and assembly of key components of bacterial processes and, 2) by inhibition of virulence traits.
Our laboratory has played a leading role in determining the functional relationship of carbapenem resistance by solving the first structure of a class D carbapenemase. We used these results as a basis to develop new antimicrobial agents aimed at treating diseases with high clinical prevalence. Thus, the experience recently acquired in our group in the structural biology of membrane proteins, provides us with a solid base to study macromolecular complexes forming part of the bacterial secretion machinery and delivery of virulence effectors to the host cell.